MAO-B inhibitors: Rasagiline, Selegiline & Safinamide, Safinamide in the management of patients – drkharkar

Dr. Siddharth Kharkar, MBBS, MD Neurology (ABPN, USA), MHS

Remember: Levodopa’s best friends are: Entacapone & Amantadine. The medications discussed here (the MAO-B inhibitors) are also supposedly “friends of levodopa/dopamine”. Except, two of them, like the older brothers Karamazov, these medications are somewhat useful but full of flaws. These medications probably belong to an older generation. I use them very sparingly, if at all. … Read more

Anticholinergics – Trihexyphenidyl, benztropine, biperiden etc.

Dr. Siddharth Kharkar, MBBS, MD Neurology (ABPN, USA), MHS

Anticholinergics: Trihexyphenidyl, Benztropine. Brandnames in India: Pacitane, Parkin etc… How do these medications work? Dopamine has an enemy in the brain, called Acetylcholine. Acetylcholine actually is a good chemical with a lot of beneficial effects, but one of the things it does is to reverse some of the actions of Dopamine. These medications are anticholinergic. … Read more

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