Dr. Siddharth Kharkar, MBBS, MD Neurology (ABPN, USA), MHS

Dr. Siddharth Kharkar is a Neurologist, Epilepsy specialist in India/Mumbai & Parkinson's disease specialist in India/Mumbai. He has trained in the best institutions including KEM hospital in Mumbai, Johns Hopkins University in USA, the University of California at San Francisco (UCSF) in USA & Kings College in London. He has been noted as one of the best neurologists in Mumbai by India Today magazine (2020, 2021) & Outlook Magazine (2020, 2022) As a neurologist in Mumbai, he provides treatment for headaches (including Migraine treatment), Stroke (paralysis), memory problems (Dementia), nerve problems such a burning, tingling, imbalance etc. He enjoys treating seemingly medically resistant cases of Epilepsy with medication adjustment. For truly resistant cases, he provides Epilepsy surgery in India / Mumbai. All epilepsy surgeries including resective (removal) Epilepsy surgeries in Mumbai are provided. His other passion is providing Parkinson's treatment in Mumbai, including Deep Brain Stimulation (DBS) for very selective cases. About Dr. Kharkar Contact / Appointments

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MAO-B inhibitors: Rasagiline, Selegiline & Safinamide, Safinamide in the management of patients – drkharkar

Dr. Siddharth Kharkar, MBBS, MD Neurology (ABPN, USA), MHS

Remember: Levodopa’s best friends are: Entacapone & Amantadine. The medications discussed here (the MAO-B inhibitors) are also supposedly “friends of levodopa/dopamine”. Except, two of them, like the older brothers Karamazov, these medications are somewhat useful but full of flaws. These medications probably belong to an older generation. I use them very sparingly, if at all. … Read more

Anticholinergics – Trihexyphenidyl, benztropine, biperiden etc.

Dr. Siddharth Kharkar, MBBS, MD Neurology (ABPN, USA), MHS

Anticholinergics: Trihexyphenidyl, Benztropine. Brandnames in India: Pacitane, Parkin etc… How do these medications work? Dopamine has an enemy in the brain, called Acetylcholine. Acetylcholine actually is a good chemical with a lot of beneficial effects, but one of the things it does is to reverse some of the actions of Dopamine. These medications are anticholinergic. … Read more

Dopamine Agonists: Ropinirole, Pramipexole, Rotigotine & Side Effect – drkharkar

Dr. Siddharth Kharkar, MBBS, MD Neurology (ABPN, USA), MHS

(Brand names in India: Pramipex, Pramipex ER, Ropark, Ropark XL) How do dopamine agonists work? These chemicals are imitators. They look just like Dopamine itself. They attach themselves to the same sites that Dopamine usually attaches itself. Therefore, they produce similar effects in the brain as Dopamine and relieve the symptoms of Parkinson’s disease. Use/Advantages: … Read more

Entacapone & Tolcapone

Dr. Siddharth Kharkar, MBBS, MD Neurology (ABPN, USA), MHS

(Brand names in India: Syncapone, Entacom plus) How do Entacapone & Tolcapone act? Entcapone is a friend of levodopa. It prevents the breakdown of levodopa by inhibiting an enzyme called COMT. The name of the enzyme is not important, what is important is that entacapone protects levodopa. Therefore, it makes the levodopa stay longer in the … Read more

Levodopa, Levodopa (Oral) Advanced Patient Information, Parkinson Disease Treatment in Mumbai – drkharkar

Dr. Siddharth Kharkar, MBBS, MD Neurology (ABPN, USA), MHS

(Brand names: Sinemet, Syndopa, Syndopa plus, Syndopa CR, Tidomet etc) Levodopa is the MOST POWERFUL, POSSIBLY BEST medication for Parkinson’s disease. If Parkinson’s was a jungle, Levodopa would be an Elephant. It is the Optimus Prime of Transformers, the Mount Everest of mountains… I could go on… How does levodopa work? In a very simple … Read more

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Noted as one of the best Neurologists in Mumbai