Seizures: Always prevent seizures during pregnancy!

This is an article from the Safe Pregnancy in Epilepsy patient guide.

Women with Epilepsy can have seizures during pregnancy. Having seizures while pregnant can hurt the baby & mother.

It is incorrect to say that pregnancy triggers seizures. But seizures can increase due to 5 important causes of seizures in pregnancy.

It is imporant to know these causes of seizures in pregnancy. Taking simple precautions can prevent seizures while pregnant.

Can I have seizures during pregnancy?


For example:

1/3rd of women with Epilepsy who get pregnant have breakthrough seizures.

This data comes from a research group from Europe. They studied 3500 pregnancies.

Can pregnancy trigger seizures?

The same European study found two other things:

  1. They found that 15% of women had worsening of seizures during pregnancy.
  2. Surprisingly, 12% of women have decreased seizures during pregnancy.

So, it is too simplistic to say that pregnancy can trigger seizures in patients with Epilepsy. If that were the case, none of the women would have decreased seizures during pregnancy.

Why do some women have decreased seizures while pregnant?

Epilepsy is not a static condition. It’s intensity waxes and wanes, like the waves in the ocean.

water 3058236 1280
Epilepsy can wax and wane, like the tides of the sea.

You may have noticed this if you have uncontrolled epilepsy. On some months, you get more seizures but cannot pinpoint why. On other months, you stop getting seizures and you don’t know why.

Some researchers strongly believe that this is the cause. That increased seizures during pregnancy are just caused by the waxing & waning nature of Epilepsy.


But this is not the complete story.

Based on research, and in my experience – there are 5 important causes of seizures in pregnancy.

To prevent seizures during pregnancy, you need to pay heed to these…

5 causes of seizures in pregnancy:

Of these 5 causes of seizures in pregnancy, 4 are more common in Epilepsy patients.

The last is equally common in women with epilepsy, and those without epilepsy.

(1) Uncontrolled Epilepsy before getting pregnant

This one is obvious.

Of all the causes of seizures in pregnancy, this is the best predictor of seizures.

In some people, Epilepsy is difficult to control. If you were having breakthrough seizures even before getting pregnant, you could have seizures while pregnant.

For example:

A study in Australia studied almost 1000 pregnancies. Women who were seizure free for at least one year were 4 times less likely to have seizures during pregnancy.

holi 2416686 1280
If you are seizure-free for 1 year or more, then you are unlikely to have seizures during pregnancy.

Here are the exact chances per that study:

  • If you are seizure-free for 1 year, less than 20% chance of having seizures during pregnancy.
  • If you are not seizure-free, 75% chance that you will have seizures during pregnancy.

Another study done in the US (the MONEAD study), had similar findings.

So, to prevent seizures during pregnancy – make sure you are seizure-free for at least 1 year before getting pregnant.

(2) Stopping seizure medications

Some women stop seizure medications when they realize they are pregnant.

They are trying to prevent harm to the baby (Teratogenicity).

This is a bad choice. This is a easily preventable cause of seizures in pregnancy.

Having seizures while pregnant can be dangerous for you and your baby.

Take your medications regularly during pregnancy.

Please don’t stop seizure medications by yourself, ever.

You can and should talk to your doctor about all options. He/she will most likely advise you not to stop medications. In most cases, it is just too risky.

Taking your medications regularly is critical to prevent seizures during pregnancy.

(3) Changing seizure medications after becoming pregnant

Some seizure medications are more likely to harm the baby. Other seizure medications are safer for the baby. You can consider switching the safer medications before pregnancy.

What about after you get pregnant? Would taking the safer medications instead be better?

This seems more reasonable than stopping seizure medications entirely. Perhaps it is. But:

Usually, this too is not a good choice. This, too, is an easily preventable cause of seizures in prengnacy.

During pregnancy
It is usually not a good idea to change seizure medications during pregnancy.

The 1998 American Academy of Neurology guidelines advise against this. They also superbly explain why:

  1. You could have uncontrolled seizures.
  2. If you change medications, the baby is exposed to two different medications. This ,may be more dangerous than any one medication.
  3. Patients go to a neurologist several weeks after becoming pregnant. By that time, there is limited advantage to change.

(4) Decreased levels of seizure medications during pregnancy

Many of the causes of seizures in pregnancy discussed so far are obvious. But many patients and caregivers are not aware of decreased levels of seizure medications.

  1. During pregnancy, the liver and kidney go into over-drive. The liver inactivates medications more quickly. The kidneys throw medications out of the body more quickly than usual.
  2. Also during pregnancy, the volume of your blood increases. The medications you are taking get diluted. Thus, the concentration of seizure medications decreases.

There are other ways in which the levels of seizure medications can decrease. These include frequent vomiting, decreased absorption, decreased binding to proteins in the blood etc…

decrease decreasing graph bars stats 512 1
Seizure medication levels in your blood decrease during pregnancy.

Ultimately, your brain gets less seizure medication. This can lead to breakthrough seizures.

To prevent seizures during pregnancy, it is critical to ensure adequate blood levels. This may mean that you need to increase the dose of epilepsy medications.

Which seizure medications are affected?

Almost all seizure medication levels decrease in pregnancy. But some seizure medications are more severely affected.

The table below shows data from a recent paper (Arfman 2020).

Marked drop in levelsMild-Moderate drop in levelsUnknown
Lamotrigine (50%)

Levetiracetam (50%)









*Phenytoin, Valproate & Topiramate should be avoided in pregnancy anyway, due to the risk of teratogenicity.

Prevent seizures during pregnancy due to reduced levels:

First of course, you should aim for good seizure control before becoming pregnant.

Then, before getting pregnant, your doctor will check a blood level. This is the “baseline blood level”.

This is the level at which your brain is happy, at which it stops having seizures. Some people suggest doing this twice before pregnancy to get the best possible estimate.

During pregnancy, your doctor may regularly check the blood level of seizure medications. If it is low, then your doctor will increase the dose.

Venipuncture using a BD Vacutainer
You may need repeated blood tests to montior seizure medication levels.

Two things to remember are:

  1. Blood tests are not available for all seizure medications.
  2. The doctor may order expensive tests called “free levels”. This test gives the most exact estimate of blood levels.

Frequency of checking blood levels:

This is variable. for example:

  1. If you are not seizure-free, then your levels are more closely monitored.
  2. If you are taking lamotrigine, then your levels are more closely monitored.

At the very minimum, blood levels are checked every trimester. In high risk cases, they are checked every month.

(5) First seizure during pregnancy

Rarely, women may have a first seizure during pregnancy. These seizures may be due to an unrelated cause.

These causes of seizures in pregnancy are rare.

  • Very high blood pressure. This produces swelling of the brain. “Eclampsia” is the medical term for this condition.
  • A blood clot in the head veins. This prevents blood from flowing out of the head. “Cerebral Venous Sinus Thrombosis” is the medical term for this condition.
  • Very rarely, Epilepsy may start in pregnancy. This is probably just random chance.

These rare conditions occur both in women with previous epilepsy, and women without epilepsy. There is no increased risk of these problems just because you have epilepsy.

Therefore I will not be discussing them further.


Women with epilepsy can have seizures during pregnancy. To prevent seizures during pregnancy, pay attention to these 5 causes of seizures in pregnancy:

    1. Ideally, you should be seizure-free for 1 year before you become pregnant.
    2. After you become pregnant, do not stop your seizure medications.
    3. After you become pregnant, usually your medication should not be changed.
    4. The levels of many medications decrease in pregnancy. Your doctor may need to increase the medication dose.
    5. Another medical problem: such as high blood pressure or blood clots.

Be sure to read the “Safe Pregnancy in Epilepsy Checklist”.

Caution: This information is not a substitute for professional care. Do not change your medications/treatment without your doctor's permission.
Dr. Siddharth Kharkar

Dr. Siddharth Kharkar

Dr. Siddharth Kharkar has been recognized as one of the best neurologists in Mumbai by Outlook India magazine and India today Magazine. He is a board certified (American Board of Psychiatry & Neurology certified) Neurologist.

Dr. Siddharth Kharkar is a Epilepsy specialist in Mumbai & Parkinson's specialist in Mumbai, Maharashtra, India.

He has trained in the best institutions in India, US and UK including KEM hospital in Mumbai, Johns Hopkins University in Baltimore, University of California at San Francisco (UCSF), USA & Kings College in London.

Call 022-4897-1800

Send Message

NeuroPlus Epilepsy & Parkinson's Clinic - Dr. Kharkar IconNeuroPlus Epilepsy & Parkinson's Clinic - Dr. Kharkar

near LIC, Dr Balabhai Nanavati hospital, near LIC, Swami Vivekananda Road, LIC Colony, Vile Parle

4.7 57 reviews

  • Avatar JAIKUMAR MANI ★★★★★ in the last week
    My experience with Dr Siddharth Kharkar was really awesome. It’s always great to be in the presence of someone who is a renowned expert in his field & … More it brings peace of mind that the advice will obviously be the correct one. In addition, his ability to convey complex workings of the human brain in such simple terms that a layman like me could easily understand was something I really appreciated. I heartily Thank Dr Kharkar for his astute advice & gladly recommend him to anyone who needs a neurologist.
  • Avatar Rohit shetye ★★★★★ 3 weeks ago
    Best Dr. we have ever meet. Dr. Listened to us patiently and gave us the proper solution. No unnecessary test or didn’t frighten us. Thank you so much … More Dr.
  • Avatar Ashish Patil ★★★★★ 4 weeks ago
    Great doctor!! Really appreciate.The doctor diagnosed me correctly and start treatment that will help me a lots to improve my condition. The doctor is … More really good, calm and his nature is down to earth, gives confidence to patient!!! Thank you!!!
  • Avatar Bianca D'silva ★★★★★ in the last week
    We had been looking for a specialist in parkinsons for a while now, for my father and when we found Dr. Siddharth Kharka's details on Google, we were … More partly relieved. Partly because, we were all very anxious not knowing how would our visit turn out. I appreciate Dr. Kharkar and his team. He was very clear in his explanations, his knowledge about parkinsons. He took the time to answer the questions we had, went over the diagnosis and started necessary treatment immediately. The only drawback we experienced was the waiting time. Overall, we left the clinic satisfied, knowing much more than when we walked in. We would highly recommend him to anyone looking for a specialist.
  • Avatar Neelam Satghare ★★★★★ 4 weeks ago
    I have visited the doctor clinic for the first timeBut he gave good advice and helped me overcomeMy doubts and queries. It was a good experience.I am very … More thankful for cooperation.
  • Avatar Nitin Ghotge ★★★★★ 4 weeks ago
    Dr.Sidharth Kharkar is one of the best neurologist i came across ....He is really genuine and focused .....We really satisfied after consultancy...
  • Avatar Krishna kumari Radhakrishnan ★★★★★ 2 months ago
    Hi Sharing my experience with Dr KharkarI had consulted with dr regarding my husband’sProblems of tremors. Dr immediately diagnosed on video consultation … More and could help him to control the tremors s of Parkinson’s disease.I found him genuinely polite and free to talk n patiently listening to the patients problem.Now my husband regained his balance n tremors controlled. Many many thanks to Dr Kharkar
  • Avatar a kumar ★★★★★ 4 weeks ago
    Dr kharkar is very nice doctor, sir explained each and every thing very nicely, and i am thankful for Dr kharkar for his treatment .
  • Avatar Nidhi Sonawane ★★★★★ 3 months ago
    I had a positive experience with the doctor. He was very sympathetic. His communication skills were good and listened with patience.
  • Avatar Ujwala Sawant ★★★★★ 4 weeks ago
    Because of Dr.kharkar sir my husband got new life. Tnx sir.
  • Avatar Mythili Balasubramanian ★★★★★ 4 months ago
    Consultation with the doctor was a very satisfying experience. Was empathetic in his approach, and responded positively to all the queries we had. Thank … More you doctor!
  • Avatar Govind Patel ★★★★★ 2 months ago
    Doctor explained very Good nice person give length time to check body
  • Avatar Sharmila Kumawat ★★★★★ 6 months ago
    Dr Siddharth is one of the best Dr I have ever met. He is kind, polite, helpful and very selfless person. I have migraine and I am his patient since more … More than 2 years. The staff is always helpful and Dr Siddharth is just beyond words for me. Thank you for ur selfless service and kindness u give to all ur patients.

Leave a Comment

India Today Magazine - 2021Noted as one of the Best Neurologists in Mumbai