Seizures: Always prevent seizures during pregnancy! Can Epilepsy Patient Get Pregnant – drkharkar

This is an article from the Safe Pregnancy in Epilepsy patient guide.

Women with Epilepsy can have seizures during pregnancy. Having seizures while pregnant can hurt the baby & mother.

It is incorrect to say that pregnancy triggers seizures. But seizures can increase due to 5 important causes of seizures in pregnancy.

It is imporant to know these causes of seizures in pregnancy. Taking simple precautions can prevent seizures while pregnant.

Can I have seizures during pregnancy?


For example:

1/3rd of women with Epilepsy who get pregnant have breakthrough seizures.

This data comes from a research group from Europe. They studied 3500 pregnancies.

Can pregnancy trigger seizures?

The same European study found two other things:

  1. They found that 15% of women had worsening of seizures during pregnancy.
  2. Surprisingly, 12% of women have decreased seizures during pregnancy.

So, it is too simplistic to say that pregnancy can trigger seizures in patients with Epilepsy. If that were the case, none of the women would have decreased seizures during pregnancy.

Why do some women have decreased seizures while pregnant?

Epilepsy is not a static condition. It’s intensity waxes and wanes, like the waves in the ocean.

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Epilepsy can wax and wane, like the tides of the sea.

You may have noticed this if you have uncontrolled epilepsy. On some months, you get more seizures but cannot pinpoint why. On other months, you stop getting seizures and you don’t know why.

Some researchers strongly believe that this is the cause. That increased seizures during pregnancy are just caused by the waxing & waning nature of Epilepsy.


But this is not the complete story.

Based on research, and in my experience – there are 5 important causes of seizures in pregnancy.

To prevent seizures during pregnancy, you need to pay heed to these…

5 causes of seizures in pregnancy:

Of these 5 causes of seizures in pregnancy, 4 are more common in Epilepsy patients.

The last is equally common in women with epilepsy, and those without epilepsy.

(1) Uncontrolled Epilepsy before getting pregnant

This one is obvious.

Of all the causes of seizures in pregnancy, this is the best predictor of seizures.

In some people, Epilepsy is difficult to control. If you were having breakthrough seizures even before getting pregnant, you could have seizures while pregnant.

For example:

A study in Australia studied almost 1000 pregnancies. Women who were seizure free for at least one year were 4 times less likely to have seizures during pregnancy.

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If you are seizure-free for 1 year or more, then you are unlikely to have seizures during pregnancy.

Here are the exact chances per that study:

  • If you are seizure-free for 1 year, less than 20% chance of having seizures during pregnancy.
  • If you are not seizure-free, 75% chance that you will have seizures during pregnancy.

Another study done in the US (the MONEAD study), had similar findings.

So, to prevent seizures during pregnancy – make sure you are seizure-free for at least 1 year before getting pregnant.

(2) Stopping seizure medications

Some women stop seizure medications when they realize they are pregnant.

They are trying to prevent harm to the baby (Teratogenicity).

This is a bad choice. This is a easily preventable cause of seizures in pregnancy.

Having seizures while pregnant can be dangerous for you and your baby.

Take your medications regularly during pregnancy.

Please don’t stop seizure medications by yourself, ever.

You can and should talk to your doctor about all options. He/she will most likely advise you not to stop medications. In most cases, it is just too risky.

Taking your medications regularly is critical to prevent seizures during pregnancy.

(3) Changing seizure medications after becoming pregnant

Some seizure medications are more likely to harm the baby. Other seizure medications are safer for the baby. You can consider switching the safer medications before pregnancy.

What about after you get pregnant? Would taking the safer medications instead be better?

This seems more reasonable than stopping seizure medications entirely. Perhaps it is. But:

Usually, this too is not a good choice. This, too, is an easily preventable cause of seizures in prengnacy.

During pregnancy
It is usually not a good idea to change seizure medications during pregnancy.

The 1998 American Academy of Neurology guidelines advise against this. They also superbly explain why:

  1. You could have uncontrolled seizures.
  2. If you change medications, the baby is exposed to two different medications. This ,may be more dangerous than any one medication.
  3. Patients go to a neurologist several weeks after becoming pregnant. By that time, there is limited advantage to change.

(4) Decreased levels of seizure medications during pregnancy

Many of the causes of seizures in pregnancy discussed so far are obvious. But many patients and caregivers are not aware of decreased levels of seizure medications.

  1. During pregnancy, the liver and kidney go into over-drive. The liver inactivates medications more quickly. The kidneys throw medications out of the body more quickly than usual.
  2. Also during pregnancy, the volume of your blood increases. The medications you are taking get diluted. Thus, the concentration of seizure medications decreases.

There are other ways in which the levels of seizure medications can decrease. These include frequent vomiting, decreased absorption, decreased binding to proteins in the blood etc…

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Seizure medication levels in your blood decrease during pregnancy.

Ultimately, your brain gets less seizure medication. This can lead to breakthrough seizures.

To prevent seizures during pregnancy, it is critical to ensure adequate blood levels. This may mean that you need to increase the dose of epilepsy medications.

Which seizure medications are affected?

Almost all seizure medication levels decrease in pregnancy. But some seizure medications are more severely affected.

The table below shows data from a recent paper (Arfman 2020).

Marked drop in levelsMild-Moderate drop in levelsUnknown
Lamotrigine (50%)

Levetiracetam (50%)









*Phenytoin, Valproate & Topiramate should be avoided in pregnancy anyway, due to the risk of teratogenicity.

Prevent seizures during pregnancy due to reduced levels:

First of course, you should aim for good seizure control before becoming pregnant.

Then, before getting pregnant, your doctor will check a blood level. This is the “baseline blood level”.

This is the level at which your brain is happy, at which it stops having seizures. Some people suggest doing this twice before pregnancy to get the best possible estimate.

During pregnancy, your doctor may regularly check the blood level of seizure medications. If it is low, then your doctor will increase the dose.

Venipuncture using a BD Vacutainer
You may need repeated blood tests to montior seizure medication levels.

Two things to remember are:

  1. Blood tests are not available for all seizure medications.
  2. The doctor may order expensive tests called “free levels”. This test gives the most exact estimate of blood levels.

Frequency of checking blood levels:

This is variable. for example:

  1. If you are not seizure-free, then your levels are more closely monitored.
  2. If you are taking lamotrigine, then your levels are more closely monitored.

At the very minimum, blood levels are checked every trimester. In high risk cases, they are checked every month.

(5) First seizure during pregnancy

Rarely, women may have a first seizure during pregnancy. These seizures may be due to an unrelated cause.

These causes of seizures in pregnancy are rare.

  • Very high blood pressure. This produces swelling of the brain. “Eclampsia” is the medical term for this condition.
  • A blood clot in the head veins. This prevents blood from flowing out of the head. “Cerebral Venous Sinus Thrombosis” is the medical term for this condition.
  • Very rarely, Epilepsy may start in pregnancy. This is probably just random chance.

These rare conditions occur both in women with previous epilepsy, and women without epilepsy. There is no increased risk of these problems just because you have epilepsy.

Therefore I will not be discussing them further.


Women with epilepsy can have seizures during pregnancy. To prevent seizures during pregnancy, pay attention to these 5 causes of seizures in pregnancy:

    1. Ideally, you should be seizure-free for 1 year before you become pregnant.
    2. After you become pregnant, do not stop your seizure medications.
    3. After you become pregnant, usually your medication should not be changed.
    4. The levels of many medications decrease in pregnancy. Your doctor may need to increase the medication dose.
    5. Another medical problem: such as high blood pressure or blood clots.

Be sure to read the “Safe Pregnancy in Epilepsy Checklist”.

Keywords – Epilepsy During Pregnancy, Can Epilepsy Patient Get Pregnant, First Seizure During Pregnancy, Emergency Treatment of Seizures in Pregnancy, What Causes Seizures During Pregnancy, Can Having a Seizure While Pregnant Hurt The Baby, Safest Seizure Medication For Pregnancy, Nocturnal Seizures During Pregnancy, Non Epileptic Seizures During Pregnancy

Caution: This information is not a substitute for professional care. Do not change your medications/treatment without your doctor's permission.
Dr. Siddharth Kharkar

Dr. Siddharth Kharkar

Dr. Siddharth Kharkar has been recognized as one of the best neurologists in Mumbai by Outlook India magazine and India today Magazine. He is a board certified (American Board of Psychiatry & Neurology certified) Neurologist.

Dr. Siddharth Kharkar is a Epilepsy specialist in Mumbai & Parkinson's specialist in Mumbai, Maharashtra, India.

He has trained in the best institutions in India, US and UK including KEM hospital in Mumbai, Johns Hopkins University in Baltimore, University of California at San Francisco (UCSF), USA & Kings College in London.

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  • Avatar Paras Prabhu ★★★★★ 6 months ago
    Out patient is epileptic from about 10 years and her seizure gotten worse during the past year with the frequency of about 3-4 times a week.So we consulted … More Dr. Kharkar. He tried a few medicines, and within 1.5-2 months now the patient is feeling very well now. There are no seizures for 14 days currently.Dr. tried to keep medicines as minimum as possible. He also tried to keep the cost of the treatment minimum.When some of the medicines started showing side-effects, he was quick to switch the medicines to the better options.Overall I think we are getting a best of the available treatments. We thank you very much Dr. Kharkar.
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    Dr Kharkar is gem of a doctor with tremendous patience, empathy, genuine concern for his patients .He guides them very methodically & scientifically … More for their neurological ill healthOur epilepsy patient is extremely happy with his treatment , Patient feels better by just visiting him too!May his selfless service to humanity flourish to reach all the needy patients!!
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    I consulted Dr Sidharth for my sister who has become very hyper and aggressive and we could not understand the issue. Keeping in mind she is someone with … More special needs Dr Sidharth was extremely understanding of the situation and did not put her through unnecessary investigation and avoided a very long stay at the hospital. He was infact more keen on her returning home to her natural environment. We highly appreciate Dr Sidharth for his effort and for looking into the matter with utmost care. It was a very difficult decision for my family to get my sister admitted but we are glad we did it under his care.Thankyou Doc.
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    my name is prashant purohit. I m become completely bed ridden from last 9 months and was unable to walk. I couldnt find out the cause even after visiting … More many doctors and many hospital in Ahmedabad nd jodhpur.started losing hope. A good friend of mine suggested to visit a neurologist. After searching a lot, I came to know about Dr. Siddharth Kharkar and took his appointment in Nanavati Hospital. He examined and said that he suffered from \u201cPKD(PAROXYSMAL KNESIGENIC DYSKNESIA\u201c. He assured us to reverse this in 5 days time. And indeed this happened. I started recovering miraculously. today I am fully well fit I m walking as normal . Many Many thanks to Dr. Siddharth Kharkhar sir for giving me a new life.
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    Dr. Kharkar is truly exceptional. He is extremely knowledgeable. But simultaneously, he is extremely patient and kind - taking the time and care to respond … More to all the questions. It is rare to come across a doctor who is not in a hurry to get on to the next patient, but instead, focuses on the one in front with full attention, expertise and compassion. A great experience.
  • Avatar N N ★★★★★ a year ago
    We visited Dr. Kharkhar for treatment regarding my mum - who is a multi-stroke patient and has aphasia. Certain medications were creating complications … More with her condition and Dr. Kharkhar was able to help mitigate the issue. We found him and his approach to be incredibly compassionate, considerate, individualized and patient-friendly. He advice is astute, up-to-date and empathetic. His treatment always comes from a deeply human place and is about seeing how to help the patient and their caregivers feel more at ease. Something that is quite rare and refreshing within the medical community.We feel that he genuinely cares about the patients that he is treating and is always kind and respectful in his communication. Moreover, his admin team is very efficient and prompt and it's a pleasure to deal with them.Would highly recommend Dr Kharkhar himself - though we must say our experience with Nanavati hospital itself has been less than ideal.Hope this helps.
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    Exceptional experience with an expert,Dr. Kharkar is a knowledge house. It is rare nowadays to find doctors with patience, knowledge, and a flair for … More handling patient’s questions, besides Dr. Kharkar’s bedside manners are exemplary. I am privileged to be treated by such an amazing soul. I have told him and will repeat it here that “I am advancing my move back to India although I am a US Citizen, because I know I am in good hands and will be well taken care of. Thanks Dr. Kharkar for your selfless service!
  • Avatar Hemant Kansara ★★★★★ a year ago
    Great doctor!! Really appreciate.The doctor diagnosed to my sister correctly and start treatment, she has good improvement after taking medicine prescribed … More by doctor as no epilepsy attake. We have good experience with the doctor. Thank you

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