Is there a Miracle Cure for PSP? [Rational PSP treatment & new research]

At present, we do not have a Miracle Cure for PSP. But that does not mean that a cure will never be available.

Diseases such as Hepatitis-C were incurable. They now have cures.

We should keep ourselves healthy for the future.

Some medications may decrease symptoms. Also, non-medication treatment is essential. Non-medication treatment includes swallowing training and balance training.

Let us read about these things.

As noted earlier, PSP is different than regular Parkinson’s disease.

PSP patients may have all the symptoms of Parkinson’s disease. They also have problems with eye movements (video below) and falling. Click here to know the complete signs.

This article is only for patients with PSP.

Will a miracle cure for PSP (Progressive Supranuclear Palsy) ever be available? 

We don’t have such a cure now. But let us put this in perspective.

When I was in medical school, medical students were scared of Hepatitis-C.

Hepatitis-C is spread like HIV, through nicks and cuts while treating patients. At the time, there was no miracle treatment. If someone were to get it, they developed severe problems like liver failure and liver cancer.

Does this disease have a miracle cure now?


In 2013, the US FDA approved a very effective medication. The name of this medication is Sofosbuvir. With other medicines, Sofosbuvir can cure 94-99% of all patients.

Sofosbuvir is a near-miraculous cure for some patients with Hepatitis C.

It is difficult to predict when such a cure will be available for PSP. Not me, nor any other doctor can make a 100% guaranteed prediction.

But, we need to take care of ourselves in the present.

We should partake of the available treatment. We need to be ready to bear the future benefits of current research.

Levodopa for PSP treatment:

As noted in another article, PSP causes decreased dopamine activity in the brain.

Levodopa is an oral tablet. It goes into the brain, where it is converted into Dopamine.

Levodopa is very useful in Parkinson’s disease. So, people have tried using it in PSP.

The benefit of Levodopa in PSP is not predictable. About 25-40% of people benefit. The improvement may be incomplete. Levodopa may also become less effective after some years.

Once it enters the brain, Levodopa is converted into Dopamine.

Overall, Levodopa can be very helpful, even if it is not a Miracle cure for PSP.

But, that is not the complete story.

PSP Subtypes and treatment

There is increasing awareness that there may be more than one variety of PSP. In 2017, the International Movement Disorders Society (MDS) described 7 variants:

1. PSP-RS (PSP-Richardson)Typical “PSP”, with severe falling and eye movement problems
2. PSP-P (PSP-Parkinsons)Almost identical to Parkinson’s disease
3. PSP-OM (Ocular movement)with eye movement problems
4. PSP-PI (Postural instability)with severe walking problems and falls
5. PSP-CBD, PSP-F, PSP-SLThese varieties are rare.

It is not essential to remember all these varieties. Please focus on number 2.

Number 2 is PSP-Parkinsonism. Which translates into “PSP that behaves like Parkinson’s disease”.

PSP-P behaves like Parkinson’s disease in it’s response to Levodopa. Although still partial, Levodopa may have a marked effect on PSP-P.

The effect may also last for a longer time, often extending over many years.

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Some variants of PSP are like Parkinson’s disease.

How many people have this variant? That is a matter of great debate. As I mentioned, this research is new, and people are still debating how to classify patients.

What it means for you – your response to Levodopa may be better than doctors earlier thought possible. We need to try it.

Amantadine for PSP treatment:

Amantadine is another medication used in Parkinson’s disease.

No one understands how it works. It was initially made to be an Antiviral, against the Flu virus. But doctors found it is useful for Parkinson’s disease.

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Amantadine can decrease freezing – the feeling that your feet are stuck to the ground.

Amantadine may also be useful in PSP. In particular, it may help you in walking better.

Patients with PSP may freeze while walking. They feel like they are stuck to the ground. They cant take another step forward.

Amantadine may reduce these “freezing” episodes.

Most doctors will try Levodopa in PSP. But many do not try Amantadine.

Almost all authorities feel it should at least be tried in all patients. The authoritative Marsden’s Textbook of Movement disorders also recommends an Amantadine trial.

Other medications for PSP

These other medications do not improve movement dramatically.

But they can be beneficial for other problems such as depression and trouble opening your eyes.

MedicationMay help with
1. AmitriptylineDepression

May improve walking.

2. DonepezilThinking problems.

May decrease “Freezing”

3.CoQ-10Still in research stages.

Not a good option at present.

May help with movement.

4. ZolpidemSame as above
5. Botox injectionsAn excellent option for a particular problem (see below)

Botox injections are often overlooked.

In some PSP patients, the muscles around the eye are forcefully contracted all the time. You may not be able to open your eyes. This is called “Blepharospasm”.

As you can imagine, not being able to open eyes is a troublesome problem.

Botox relaxes muscles. Botox helps to keep the eyes open.

Botox is the same medication that some people use to smoothen out skin wrinkles.

Here is an excellent video of the process:

Botox injections are relatively safe. It takes about 5-10 minutes in the doctor’s office.

The main downside is that they are somewhat expensive.

Reference / Additional reading:

  1. A Review of Treatment Options for Progressive Supranuclear Palsy – Stamelou et al., CNS drugs – 2016


Will Deep Brain Stimulation (DBS) be the Miracle Cure for PSP?

DBS is not very useful for PSP at present. But perhaps it will be in the future.

Deep Brain Stimulation (DBS) is a small device. Through a thin wire, it can simulate parts of the brain.

DBS is beneficial for Parkinson’s disease. In Parkison’s disease, either the Subthalamic Nucleus (STN) or the Globus Pallidus Interna (GPi) is stimulated.

But, stimulation of these parts does not help PSP. So, PSP is not routinely treated by DBS.

DBS e1578942163505
DBS works for Parkinson’s disease. Ongoing research aims to make the use of DBS in PSP successful as well.

Newer research seems promising.

There is another brain area called the Pedunculopontine Nucleus (PPN). Newer research has shown that PSP DBS (Deep Brain Stimulation) may be done in this area.

We still are finding which stimulation setting would work in PSP. For example, high-frequency stimulation may work better in PSP.

Another newer concept is the stimulation of two areas together. Some doctors have suggested that stimulation of the PPN and GPi at the same time may lead to success in the use of DBS for PSP. This needs to be proven.

DBS can be dramatically useful in Parkinson’s disease. Whether DBS will be the Miracle Cure for PSP is something only time will tell.

At present, DBS for PSP is a research endeavour. You may choose to take part in a well-designed, research study of DBS in PSP.

Here is one such study at Harvard / Beth-Israel Deaconess Medical centre. [Study of Gait Analysis in Neurological disease]

Promising medication trials in PSP

Besides DBS, researchers are also studying medications for PSP.

These research trials are based on very complex science.

One medication (C2N-8E12) may remove the waste product called “Tau” from the brain. “Tau” is supposed to be the toxic agent responsible for producing PSP.

You can read more about research in medications & DBS for PSP by reading this paper by Dr. Moretti, a researcher from Italy. [Click here]

Moretti Advances in treatment of Atypical Parkinsonism
Click here for an excellent (but detailed) summary of future treatments for PSP.

PSP treatment without medications

“Treatment” doesn’t mean only medications.

The two most important complications of PSP are:

  1. Trouble swallowing, which can lead to “Aspiration.”
  2. Falling
In PSP patients, food may go into the windpipe (lungs) instead of the foodpipe (stomach). This is called Aspiration. It is absolutely critical to prevent aspiration.

Physiotherapy and balance training is useful to prevent falling. Swallowing therapy and education is helpful to avoid aspiration.

You can read more about preventing Falling and Aspiration in these two articles:

  1. Learn how to Prevent aspiration
  2. Learn how to Prevent Falling

A continually updated list of PSP research studies

If you or your loved one has PSP, you may consider participating in a research study.

In addition to talking to your neurologist, the website is a good starting point to finding such studies.

Please click on this link, it contains almost all studies being conducted in the US, and most studies being conducted in Europe. In my experience, coverage of studies being conducted in other countries is sometimes patchy.

Click here for the latest PSP trials on

Caution: This information is not a substitute for professional care. Do not change your medications/treatment without your doctor's permission.
Dr. Siddharth Kharkar

Dr. Siddharth Kharkar

Dr. Siddharth Kharkar has been recognized as one of the best neurologists in Mumbai by Outlook India magazine and India today Magazine. He is a board certified (American Board of Psychiatry & Neurology certified) Neurologist.

Dr. Siddharth Kharkar is a Epilepsy specialist in Mumbai & Parkinson's specialist in Mumbai, Maharashtra, India.

He has trained in the best institutions in India, US and UK including KEM hospital in Mumbai, Johns Hopkins University in Baltimore, University of California at San Francisco (UCSF), USA & Kings College in London.

Call 022-4897-1800

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10 thoughts on “Is there a Miracle Cure for PSP? [Rational PSP treatment & new research]”

  1. My father diagnosed with PSP last year. We consulted with Neurologists and started the treatment(medicines and few exercises). But there is not much improvement, he has difficulty in maintaining balance while standing up from sitting and lying down position and falls frequently. plss sugest some treatment.

  2. Hi Sir,
    My mother has been diagnosed with psp since last 3 years. Doctor prescribed Syndopa tablet, her situation is getting worse. Is cell based therapy or botox treatment will help?


    • For PSP:
      – The diagnosis needs to be firm / sure. A MRI with morphometric measurements (checking the actual volume of the midbrain) can be confirmatory.
      – Botox therapy can help the patient in opening his/her eyes. It is not very useful for other things.
      – Stem cell therapy is addressed in detail elsewhere in this guide. As of this date, stem cell therapy is a good research prospect and you can participate in a well-designed research trial for the same. However, it is not currently approved for routine treatment of PSP patients.

  3. My mother has been diagnosed with psp almost 2 years back. She’s on a very rapid decline so any ready of hope is good. Any idea when a treatment will be available and if it’s a good idea to participate in clinical trials and would you be able to recommend any ongoing trials?

    • It is difficult to say when a treatment will be available. At the present time, there are not many medications that are close to being approved and are dramatic cures. Yes, it is definitely a good idea to get involved in clinical trials. The website will help you find a clinical trial close to where you live.

      Dr. Siddharth Kharkar

  4. My father has been aspirating for the past year and has developed aspirational pneumonia. I think it is because of his inability to swallow. I have got two contradictory diagnoses from the doctors at NIMHANS and Narayana Hrudayalaya where one set believes it’s PSP and the latter believes it is Parkinson’s. He is in and out of ICU at the moment and I need to understand how can I best manage the aspirations. Could you please point me to someone who we can consult?

    • Aspiration is common both in PSP and Parkinson’s disease. It definitely is more common in PSP, but just the presence of aspiration is not enough to make a diagnosis of PSP.

      There are two features that are more specific for PSP: inability to look down, and shrinkage of a part of the brain called the midbrain.

      Regarding the latter, rather than just estimating it visually, some radiology centres can actually measure the volume of the midbrain, and compare it mathematically to a nearby region of the brain called the pons. This is called the midbrain/pons ratio, and if it is disproportionately low, it is quite specific for PSP.

      Sometimes, the initial MRI may not show the shrinkage. Repeating the MRI after a year may help to confirm the diagnosis.

      Dr. Siddharth Kharkar

  5. Because of falls, loss of appetite, tremors, and other clinical symptoms, I was diagnosed with PSP. Then, a few months later, a DatScan revealed that I did not have PSP. What could explain the symptoms of not PSP??

    • It would not be proper to comment on your case in particular. But if I may, I’ll make a few general comments:

      – All tests including the dat scan are fallible. A dat scan may be negative even in a case of Parkinsonism/psp.

      – So the clinical history and exam is what all doctors base their diagnosis on.

      – if the history and exam suggest an alternative etiology – such as thyroid problems, vitamin deficiencies etc… A full recovery may be possible.

      – I have an article on this website about the mimics of parkinsons/parkinsonism. I think you will find it interesting.

      – Please talk to your doctor in detail about your problems. If needed a second opinion is, of course, a good option and is well within your rights as a patient.


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